Digital Business Ecosystem implies several distinctive features including the heterogeneity of involved actors, their interdependence in the exchange of resources, the dynamic nature of their relationships, and the need for self-organization. To successfully design and develop such ecosystems, it is essential to clearly define the business scope, delineate the roles and responsibilities of each participating company, organization and individual, map out their interactions and dependencies, and leverage a range of underlying technologies and diverse data. Furthermore, this process must include an assessment of the ecosystem’s resilience, gauging its ability to achieve its objectives in the face of challenges. This involves identifying and modeling resilience indicators to ensure the ecosystem’s capacity to adapt and thrive under changing conditions.